(E)-2-[[3-(3-Methoxy-4-propargyloxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid

Name	FT011
Synonyms	FT011 SHP-627 (E)-2-[[3-(3-Methoxy-4-propargyloxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid Benzoic acid, 2-[[(2E)-3-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]-1-oxo-2-propen-1-yl]amino]-
CAS	1001288-58-9

Molecular Formula	C20H17NO5
Molar Mass	351.35
Density	1.307±0.06 g/cm3(Predicted)
Boling Point	618.9±55.0 °C(Predicted)
Solubility	DMSO: ≥ 29 mg/mL
pKa	3.45±0.36(Predicted)
Storage Condition	-20℃
In vivo study	FT011 (100 mg/kg b.i.d., p.o., for 4 weeks) improves the cardiac function and and myocardial remodeling in myocardial infarction rats. Animal Model: Seventy male Sprague Dawley (SD) rats (weighing 200-250 g) Dosage: 100 mg/kg Administration: B.I.D., p.o. on day 7 after surgery, for 4 weeks Result: Increased ejection fraction, fraction shortening and preload recruitable stroke work.

Last Update：2024-01-02 23:10:35

bioactivity	FT011 is an anti-fibrotic agent that reduces mRNA expression of collagen I and III and inhibits collagen synthesis.
in vivo study	FT011 (100 mg/kg B.I. d., p.o., for 4 weeks) improvements the cardiac function and and myocardial reconstruction in myocardial infection rats. Animal Model: Seventy male Sprague Dawley (SD) rats (weighting 200-250g) Dosage: 100 mg/kg Administration: B.I.D., p.o. on day 7 after surgery, for 4 weeks Result: Increased ejection fraction, fraction shortening and preload recruitable stroke work.
Animal Model:	Seventy male Sprague Dawley (SD) rats (weighing 200-250 g)
Dosage:	100 mg/kg
Administration:	B.I.D., p.o. on day 7 after surgery, for 4 weeks
Result:	Increased ejection fraction, fraction shortening and preload recruitable stroke work.

Last Update：2024-04-09 15:16:41

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Product Name: FT011 Visit Supplier Webpage Request for quotation
CAS: 1001288-58-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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(E)-2-[[3-(3-Methoxy-4-propargyloxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid Request for Quotation